The new release properly does site-packages isolation, so pexs will no longer pull in locally installed packages on newer distros. You can use PEX_INHERIT_PATH=1 to revert to the (almost) the old behavior.
Other niceties include:
- access_zipped_assets() [just a pkg_resources crawl; has nothing to do with zips]
- perf improvements for extracting prebuilt packages
- ~/.pexrc, /etc/pexrc for local/global pex settings (like PEX_ROOT)
- a bunch of new env variables: PEX_SCRIPT/PEX_PATH/PEX_PYTHON. I personally don't recommend using PEX_PATH (allows combining pexs) :(.